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-synuclein, and that is a key part of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, and that is an E3 ubiquitin ligase and brings about endoplasmic reticulum (ER) anxiety, suggest that dysfunction of the intracellular proteinase devices, including ubiquitin-proteasome method or lysosomal system, which gets rid of unneeded toxic pro